Selected publications

1

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Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal

Sci Adv. 2020 Jun;6(26): PMID: 32637608 

Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N.

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Therapies targeting FLS and TNF can have synergistic effects

Nat Rev Rheumatol​. 2020 Sep;16(9):473 

PMID: 32737429

Onuora S

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2

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Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity. 

J Clin Invest. 2019 Mar 1;129(3):1193-1210. PMID: 30620725

Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N

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How T reg cells lose FOXP3

Nat Rev Rheumatol​. 2019.Mar;15(3):127. 

PMID: 30670869

Bernard NJ

3

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Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 

Nat Commun. 2018 Jul 6;9(1):2627. PMID: 29980684;

Zhao M*, Svensson MND*, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M

*Co-first authorship

4

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Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice. 

Arthritis Rheumatol. 2016 Feb;68(2):359-69. PMID: 26414708

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

5

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Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.  

Sci Transl Med. 2015 May 20;7(288):288ra76. PMID: 25995222

Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.

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6

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Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination.  

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):PMID: 26627255

Svensson MN*, Andersson KM, Wasén C, Erlandsson MC, Nurkkala-Karlsson M, Jonsson IM, Brisslert M, Bemark M, Bokarewa MI.

* corresponding author

7

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Resistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis.  

Arthritis Rheum. 2011 Oct;63(10):2894-904. PMID: 21739426.

Boström EA, Svensson M*, Andersson S, Jonsson IM, Ekwall AK, Eisler T, Dahlberg LE, Smith U, Bokarewa MI

* corresponding author

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