Svensson Lab
Selected publications
1
Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal
Sci Adv. 2020 Jun;6(26): PMID: 32637608
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N.
Highlight
Therapies targeting FLS and TNF can have synergistic effects
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publication list and research profiles
2
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
J Clin Invest. 2019 Mar 1;129(3):1193-1210. PMID: 30620725
Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N
Highlight
How T reg cells lose FOXP3
3
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
Nat Commun. 2018 Jul 6;9(1):2627. PMID: 29980684;
Zhao M*, Svensson MND*, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M
*Co-first authorship
4
Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.
Arthritis Rheumatol. 2016 Feb;68(2):359-69. PMID: 26414708
Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.
5
Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.
Sci Transl Med. 2015 May 20;7(288):288ra76. PMID: 25995222
Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.
Highlighted in Nature Reviews Rheumatology:
Manipulating the FLS 'proteoglycan switch' could offer a new approach to RA therapy
Highlighted in NIH Spotlight on Research:
Discovery Opens Door to New Class of Medicines forRheumatoid Arthritis
Awarded the 2016 Lee C. Howley Sr. Prize for Arthritis Scientific Research.
Cover illustration
6
Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination.
Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):PMID: 26627255
Svensson MN*, Andersson KM, Wasén C, Erlandsson MC, Nurkkala-Karlsson M, Jonsson IM, Brisslert M, Bemark M, Bokarewa MI.
* corresponding author
7
Resistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis.
Arthritis Rheum. 2011 Oct;63(10):2894-904. PMID: 21739426.
Boström EA, Svensson M*, Andersson S, Jonsson IM, Ekwall AK, Eisler T, Dahlberg LE, Smith U, Bokarewa MI
* corresponding author
Cover illustration
Links to full publication list and research profiles